Malaria in pregnancy linked to brain damage in babies
Babies whose mothers contract malaria during pregnancy could suffer
later problems, including depression and learning difficulties,
according to a study done in mice.
The study found that unborn babies whose mothers were infected with
malaria had lower levels of the substances needed for normal brain
development and function. It was published in the journal PLOS Pathogens
on 24 September.
The reduction was thought to be caused by excess activation of an
immune response in the mother that is used to tackle malaria, but that
also appears to interfere with the production of these substances, the
researchers say.
As a result of their mothers’ malaria infection, the mice developed
symptoms of depression and cognitive impairment after birth, such as
memory problems and reduced social interaction, the study says.
“We need to confirm the findings in humans,” says Kevin Kain,
co-author of the study from the University of Toronto in Canada.
The research was carried out to investigate how malaria might affect
unborn children. This is particularly important as pregnant women have a
higher risk than other women of being infected with the malaria parasite
Plasmodium falciparum and of developing a severe form of the infection.
This is because pregnancy reduces their immunity to malaria.
Malaria is estimated to affect around 200 million people a year. The
disease is most dangerous for children living in poor areas, with most
of the 90 per cent of malaria deaths in Africa occurring among the
under-fives, according to the World Health Organization.
Harry Tagbor, a public health researcher at Kwame Nkrumah University
of Science and Technology in Ghana, says previous research on malaria
and unborn babies focused on maternal anaemia and resulting low birth
weight, rather than on brain development.
He told SciDev.Net that the findings in mice should motivate
researchers to investigate how malaria in pregnancy affects mental
health development in humans.
The research team also tried to stop malaria from harming unborn baby
mice by blocking the immune response that had become excessively
activated.
This restored the key brain substances to their normal levels, so the
baby mice no longer developed symptoms of depression and mental
impairments after birth.
This treatment would be too expensive to roll out on a large scale in
humans, admits Kain. Nonetheless, the team’s “vital goal” is to find a
safe and inexpensive human treatment, he says.
- SciDevNet |