
Genetic data could point to ancient traits ... or
modern relatives:
Scientists decode
5,200-year-old Iceman's genes
Researchers have sequenced Oetzi the Iceman's genome and hope to be
able to locate any living descendants.
Oetzi the Iceman, the Neolithic mummy found accidentally in the
eastern Alps by German hikers in 1991, has offered researchers all sorts
of clues to life 5,200 years ago, from his goat-hide coat to the meat
and unleavened bread in his stomach to the arrow wound in his shoulder.
Now scientists stand poised to find out a whole lot more about
Iceman, who also goes by Frozen Fritz and Similaun Man.

Pic courtesy - South Tyrol Museum of Archaeology |
They recently finished sequencing the Iceman's genome, which took
about three months - a feat made possible by whole genome sequencing
technology.
With that map of his genes in hand, researchers are moving onto to a
whole new array of questions, according to Albert Zink, head of the
European Institute for Mummies and the Iceman at the European Academy of
Bozen/Bolzano (EURAC) in Italy.
"Some are very simple, like so 'What was really the eye colour of the
Iceman? What was really his hair colour?'" Zink said. There are more
complicated questions, too. Zink and others are curious about any
genetic evidence of disease in the Iceman and the composition of his
immune system.
And there's the big one, he told LiveScience: "Are there any living
relatives of the Iceman still around?"
Scientists have already taken a stab at this question when they
analysed DNA from Iceman's mitochondria energy-producing centers of
cells and compared the results with groups of living individuals.
They did not find any matches, suggesting that his maternal lineage
is either very rare or died out. (Mitochondrial DNA is passed down from
mothers to their children and so would only provide relatives on
Iceman's mum's side of the family).
"We have to take into account this is only the maternal lineage," he
said, referring to the mitochondrial study. "And not all people are
tested."
Until now, scientists hadn't mapped the DNA within the nuclei of his
cells. For humans, nuclear DNA contains six billion base pairs, while
mitochondrial DNA has only 15,000 to 17,000, according to Zink.
Collaboration with EURAC's Institute for Genetic Medicine is expected
to widen the field, because it has collected genetic information on a
large number of people living in the region, the most likely prospects
for Iceman's descendants. That, in addition to the fact that scientists
can compare his entire nuclear genome, gives Zink hope for getting to
the bottom of some of Iceman's mysteries.
Iceman's genome was sequenced using a sample taken previously from
his hip bone, Zink said. Zink and a colleague from the Institute of
Human Genetics at the University of Tuebingen were able to complete the
genomic sequencing with amasing speed thanks to collaboration with
Andreas Keller of the biotechnology firm Febit, according to Zink. |