Scientists discover new therapy to cure HIV
7 Dec TOI
Scientists have found a new way to clean the remaining human
immunodeficiency virus (HIV) from the bodies of infected patients after
they have been treated with antiretroviral therapy.
Scientists used radioimmunotherapy (RIT) to destroy remaining human
immunodeficiency virus (HIV)-infected cells in the blood samples of
patients treated with antiretroviral therapy, offering the promise of a
strategy for curing HIV infection.
Ekaterina Dadachova from Albert Einstein College of Medicine in the
Bronx, New York and a team of researchers administered RIT to blood
samples from 15 HIV patients treated with highly active antiretroviral
therapy (HAART). RIT, which has historically been employed to treat
cancer, uses monoclonal antibodies - cloned cells that are recruited by
the immune system to identify and neutralise antigens.
“In RIT, the antibodies bind to the infected cells and kill them by
radiation. When HAART and RIT are used together, they kill the virus and
the infected cells, respectively,” said Dadachova, the study's lead
author. Dadachova's team paired the monoclonal antibody (mAb2556)
designed to target a protein expressed on the surface of HIV-infected
cells with the radionuclide Bismuth-213. Researchers found that RIT was
able to kill HIV-infected lymphocytes previously treated with HAART,
reducing the HIV infection in the blood samples to undetectable levels.
“The elimination of HIV-infected cells with RIT was profound and
specific. The radionuclide we used delivered radiation only to
HIV-infected cells without damaging nearby cells,” Dadachova said. An
important part of the study tested the ability of the radiolabeled
antibody to reach HIV-infected cells in the brain and central nervous
system.
Using an in vitro human blood brain barrier model, the researchers
demonstrated that radiolabeled mAb2556 could cross the blood brain
barrier and kill HIV-infected cells without any overt damage to the
barrier itself. “Antiretroviral treatment only partially penetrates the
blood brain barrier, which means that even if a patient is free of HIV
systemically, the virus is still able to rage on in the brain, causing
cognitive disorders and mental decline,” Dadachova said.
“Our study showed that RIT is able to kill HIV-infected cells both
systemically and within the central nervous system,” said Dadachova.
According to Dadachova, clinical trials in HIV patients are the next
step for the RIT treatment. Results of the study were presented at the
annual meeting of the Radiological Society of North America (RSNA).
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