Neanderthal genome reveals early human interbreeding and inbreeding
The most complete sequence to date of the Neanderthal genome, using
DNA extracted from a woman's toe bone that dates back 50,000 years,
reveals a long history of interbreeding among at least four different
types of early humans living in Europe and Asia at that time, according
to University of California, Berkeley, scientists.
Population geneticist Montgomery Slatkin, graduate student Fernando
Racimo and post-doctoral student Flora Jay were part of an international
team of anthropologists and geneticists who generated a high-quality
sequence of the Neanderthal genome and compared it with the genomes of
modern humans and a recently recognized group of early humans called
Denisovans.
The comparison shows that Neanderthals and Denisovans are very
closely related, and that their common ancestor split off from the
ancestors of modern humans about 400,000 years ago. Neanderthals and
Denisovans split about 300,000 years ago.
Though Denisovans and Neanderthals eventually died out, they left
behind bits of their genetic heritage because they occasionally
interbred with modern humans. The research team estimates that between
1.5 and 2.1 percent of the genomes of modern non-Africans can be traced
to Neanderthals.
Denisovans also left genetic traces in modern humans, though only in
some Oceanic and Asian populations. The genomes of Australian
aborigines, New Guineans and some Pacific Islanders are about six
percent Denisovan genes, according to earlier studies. The new analysis
finds that the genomes of Han Chinese and other mainland Asian
populations, as well as of native Americans, contain about 0.2 percent
Denisovan genes.
The genome comparisons also show that Denisovans interbred with a
mysterious fourth group of early humans also living in Eurasia at the
time.
That group had split from the others more than a million years ago,
and may have been the group of human ancestors known as Homo erectus,
which fossils show was living in Europe and Asia a million or more years
ago.
“The paper really shows that the history of humans and hominins
during this period was very complicated,” said Slatkin, a UC Berkeley
professor of integrative biology. “There was lot of interbreeding that
we know about and probably other interbreeding we haven't yet
discovered.”
In another analysis, Jay discovered that the Neanderthal woman whose
toe bone provided the DNA was highly inbred. The woman's genome
indicates that she was the daughter of a very closely related mother and
father who either were half-siblings who shared the same mother, an
uncle and niece or aunt and nephew, a grandparent and grandchild, or
double first-cousins (the offspring of two siblings who married
siblings).
Further analyses suggest that the population sizes of Neanderthals
and Denisovans were small and that inbreeding may have been more common
in Neanderthal groups than in modern populations.
As part of the new study, Racimo was able to identify at least 87
specific genes in modern humans that are significantly different from
related genes in Neanderthals and Denisovans, and that may hold clues to
the behavioural differences distinguishing us from early human
populations that died out.
- MNT
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