Breakthrough with stem cells can ‘end need for transplants’
Living mice able to
produce the cells capable of helping to repair a damaged heart
Scientists have created stem cells within the body of laboratory mice
for the first time in a landmark study showing that it may be possible
one day to repair damaged human organs in situ without the need for
transplant operations.
Until now stem cells created by a new genetic engineering technique
have only been created in vitro in the laboratory, but the researchers
were able to perform gene therapy on living mice to generate the stem
cells in vivo.
If the work can be transferred safely to humans it raises the
possibility of generating stem cells at the site of a diseased organ,
such as heart or pancreas, so that a person’s own stem cells could be
generated to repair any damaged tissue.
“We think this opens new possibilities in regenerative medicine...
One possible advantage over other stem cell techniques is that the cells
are already there in the right place with the possibility of becoming
functional cells - with no need for grafts,” said Manuel Serrano of the
Spanish National Cancer Research Centre in Madrid. “We can now start to
think about methods for inducing regeneration locally and in a
transitory manner for a particular damaged tissue,” said Dr Serrano, who
led the study published in the journal Nature .
Stem cells can be taken from early embryos or be created from
ordinary skin cells by injecting them with four genetic factors that
re-programme the adult cells back to their embryonic state.
- The Independent
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