Diabetes quadruples birth defects risk - Researchers
11 Feb BBC
The risk of birth defects increases four-fold if the pregnant mother
has diabetes, researchers say.
The Newcastle University study, published in the journal
Diabetologia, analysed data from more than 400,000 pregnancies in North
East England.
The risk of defects such as congenital heart disease and spina bifida
were increased.
National guidelines already recommend having good control over blood
sugar levels before trying to conceive.
Both Type 1 diabetes, which tends to appear in childhood, and Type 2
diabetes, often linked to diet, lead to problems controlling the amount
of sugar in the blood.
This is known to cause problems in pregnancy, such as birth defects,
miscarriage and the baby being overweight due to too much sugar. There
is concern that rising levels of diabetes, particularly Type 2, could
make the issue worse.
Researchers analysed data from 401,149 pregnancies between 1996 and
2008 - 1,677 women had diabetes.
The risk of birth defects went from 19 in every 1,000 births for
women without pre-existing diabetes to 72 in every 1,000 births for
women with diabetes. Their report said that sugar levels in the run-up
to conception were the “most important” risk factor which could be
controlled. The lead researcher, Dr Ruth Bell from Newcastle University,
told the BBC: “Many of these anomalies happen in the first four to six
weeks.”
She said the number of pregnancies with poor sugar control were “more
than we would like”.
“It is a problem when the pregnancy is not intended or when people
are not aware they need to talk to their doctors before pregnancy,” she
said. Guidelines from the National Institute of Health and Clinical
Excellence say women should reduce their levels of glycated haemoglobin
(HbA1c - a marker for long-term blood sugar control) to below 6.1%
before trying to have a baby.
Dr Bell said: “The good news is that, with expert help before and
during pregnancy, most women with diabetes will have a healthy baby.
“The risk of problems can be reduced by taking extra care to have the
best possible glucose control before becoming pregnant.”
The charity Diabetes UK funded the study. Its director of research,
Dr Iain Frame, said: “We need to get the message out to women with
diabetes that if they are considering becoming pregnant, then they
should tell their diabetes healthcare team, who will make sure they are
aware of planning and what next steps they should be taking.
“It also highlights the importance of using contraception if you are
a woman with diabetes who is sexually active but not planning to become
pregnant.”
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